When Esther Greenwood wins an internship, she is elated, believing she will finally realize her dream to become a writer. But in between the cocktail parties and piles of manuscripts, her life begins to slide out of control. She finds herself spiraling into depression and eventually a suicide attempt, as she grapples with difficult relationships and a society which refuses to take women's aspirations seriously.

Surrounded by his children, who all seem to be going through life crises, and his wife, who is wrestling with her own demons, small-town Texas local Duane Moore can't seem to make sense of his life anymore. To the perplexity of his family and friends, he ditches his pickup, starts walking everywhere, and moves to a crude shack six miles out of town. But his attempts to go off the grid are far from successful, and he struggles with increasing depression....

Middle schooler Natalie's year-long assignment to answer a question using the scientific method leads to truths about her mother's depression and her own cultural identity.

While living with her Gram in Vermont, eleven-year-old Aubrey writes letters as a way of dealing with losing her father and sister in a car accident, and then being abandoned by her grief-stricken mother.

When her sixteen-year-old sister is hospitalized for depression and her parents want to keep it a secret, fourteen-year-old Elena tries to cope with her own anxiety and feelings of guilt that she is determined to conceal from outsiders.

A princess and a peasant girl, who hides a sorrow in a town where everyone lives with unending joy, embark on a dangerous quest to outwit a centuries-old warning foretelling the fall of the Monarchy.

Since Eureka's mother drowned, she wishes she were dead too, but after discovering that an ancient book is more than a story Eureka begins to believe that Ander is right about her being involved in strange things--and in grave danger.

When Margaret's fiancé, John, is hospitalized for depression, she faces a choice: carry on with their plans, or back away from the suffering it may bring her. She decides to marry him. What follows is the unforgettable story of what unfolds from this act of love and faith. At the heart of it is their eldest son, Michael, a brilliant, anxious music fanatic, and the story of how, over the span of decades, his younger siblings--the responsible Celia...